Temazepam


w231



General information:


Withdrawn ID: w231
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N05CD07
Molecular Formula: C16H13ClN2O2
Molweight: 300.74



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1959
First death: 1992
First withdrawn: 2004
Last withdrawn: 2004
Reference: https://www.ncbi.nlm.nih.gov/pubmed/6145108



Side-effects:

Total reported cases (submitted by medical professionals) with Temazepam as primary suspect: 679


Reported final outcomes:
Death: 442
Hospitalization (initial or prolonged): 110
Life-Threatening condition: 20
Intervention required to prevent permanent impairment/damage: 9
Disability: 7


Reported side-effects:

Side-effect Case number
DEATH186
COMPLETED SUICIDE136
TOXICITY TO VARIOUS AGENTS64
DRUG INTERACTION43
DRUG ABUSE36
DRUG INEFFECTIVE27
OVERDOSE26
CARDIO-RESPIRATORY ARREST24
SOMNOLENCE21
INSOMNIA19
FALL19
CONFUSIONAL STATE19
POISONING18
LOSS OF CONSCIOUSNESS18
DRUG TOXICITY18
INTENTIONAL OVERDOSE17
WITHDRAWAL SYNDROME16
THERAPEUTIC AGENT TOXICITY14
SUICIDE ATTEMPT14
HEADACHE12
AGITATION12
VOMITING11
MEDICATION ERROR11
DIZZINESS11
ANXIETY11
ACCIDENTAL OVERDOSE11
ABNORMAL BEHAVIOUR11
RESPIRATORY DEPRESSION10
AMNESIA10
MULTIPLE DRUG OVERDOSE9
DYSARTHRIA9
CARDIAC ARREST9
TACHYCARDIA8
SUICIDAL IDEATION8
SEDATION8
PHARMACEUTICAL PRODUCT COMPLAINT8
MENTAL STATUS CHANGES8
LETHARGY8
HALLUCINATION8
GAIT DISTURBANCE8
RESPIRATORY ARREST7
NAUSEA7
INCORRECT ROUTE OF DRUG ADMINISTRATION7
HYPERHIDROSIS7
FATIGUE7
SOMNAMBULISM6
Seizure6
RESPIRATORY FAILURE6
PANIC ATTACK6
ISCHAEMIA6
HYPOTENSION6
DEPRESSION6
DELIRIUM6
CATATONIA6
AGGRESSION6
ROAD TRAFFIC ACCIDENT5
PSYCHOTIC DISORDER5
PARANOIA5
NIGHTMARE5
MENTAL DISORDER5
HEART RATE INCREASED5
FEELING ABNORMAL5
EMOTIONAL DISORDER5
DRY MOUTH5
DEPRESSED LEVEL OF CONSCIOUSNESS5
CHILLS5
CHEST PAIN5
SYNCOPE4
SEROTONIN SYNDROME4
PULMONARY CONGESTION4
PRODUCT SUBSTITUTION ISSUE4
Product dispensing error4
PNEUMONIA4
Off label use4
MYDRIASIS4
Maternal exposure during pregnancy4
MALAISE4
HYPONATRAEMIA4
DRUG WITHDRAWAL SYNDROME4
DRUG DISPENSING ERROR4
DIARRHOEA4
DEPRESSED MOOD4
CONSTIPATION4
COMA4
Cognitive disorder4
CARDIOMEGALY4
WEIGHT INCREASED3
VISUAL DISTURBANCE3
VISION BLURRED3
Urinary tract infection3
URINARY INCONTINENCE3
UNRESPONSIVE TO STIMULI3
TREMOR3
Transient ischaemic attack3
TINNITUS3
THROAT IRRITATION3
Thinking abnormal3
Substance abuse3
SLEEP APNOEA SYNDROME3
Septic shock3
PRURITUS3
PRODUCT QUALITY ISSUE3
Pollakiuria3
POISONING DELIBERATE3
PNEUMONIA ASPIRATION3
PAIN IN EXTREMITY3
OXYGEN SATURATION DECREASED3
OEDEMA PERIPHERAL3
NERVOUSNESS3
MYALGIA3
MULTIPLE DRUG OVERDOSE INTENTIONAL3
METABOLIC ACIDOSIS3
MEMORY IMPAIRMENT3
INCORRECT DOSE ADMINISTERED3
HYPOXIA3
HYPERTONIA3
HYPERTENSION3
HIP FRACTURE3
HALLUCINATION, VISUAL3
GRAND MAL CONVULSION3
GENERAL PHYSICAL HEALTH DETERIORATION3
ECHOLALIA3
Drug-induced liver injury3
DRUG SCREEN POSITIVE3
DRUG EFFECT INCREASED3
DRUG DEPENDENCE3
COUGH3
Bradycardia3
ATRIOVENTRICULAR BLOCK FIRST DEGREE3
APNOEA3
ANGER3
Vertigo2
Urinary retention2
Treatment failure2
Transcription medication error2
STRESS2
Sleep disorder2
Sinus tachycardia2
SEPSIS2
RHABDOMYOLYSIS2
Restlessness2
Respiration abnormal2
RENAL FAILURE2
Rash2
PYREXIA2
Pulse abnormal2
PULMONARY OEDEMA2
PROSTATE CANCER2
Product physical issue2
Product dose omission issue2
PROCEDURAL COMPLICATION2
PLATELET DISORDER2
PHOTOSENSITIVITY REACTION2
PHOTOPHOBIA2
PALPITATIONS2
OROPHARYNGEAL PAIN2
OPTIC NEURITIS2
No adverse event2
Neutrophil count increased2
MYOCARDIAL INFARCTION2
MUSCULOSKELETAL STIFFNESS2
MUSCLE SPASMS2
Multiple organ dysfunction syndrome2
Mood swings2
MOBILITY DECREASED2
MENTAL IMPAIRMENT2
Maternal exposure during breast feeding2
Logorrhoea2
Limb discomfort2
Irritability2
Intestinal ischaemia2
Intentional product misuse2
Incorrect route of product administration2
HYPOTHERMIA2
HYPERSENSITIVITY2
HYPERKALAEMIA2
Hepatotoxicity2
HEPATITIS ACUTE2
Hepatic congestion2
HEAD INJURY2
HANGOVER2
HALLUCINATIONS, MIXED2
HALLUCINATION, OLFACTORY2
FLUSHING2
Extra dose administered2
EMOTIONAL DISTRESS2
ELECTROCARDIOGRAM QT PROLONGED2
Dystonia2
Dyspraxia2
DYSPNOEA2
Dysphagia2
DYSPEPSIA2
Drug tolerance2
Drug reaction with eosinophilia and systemic symptoms2
DRUG LEVEL INCREASED2
DRUG EFFECT DECREASED2
Drug dose omission2
Disturbance in attention2
DISSOCIATION2
DEPENDENCE2
DEEP VEIN THROMBOSIS2
Coordination abnormal2
CONVULSION2
Condition aggravated2
CLONUS2
Claustrophobia2
CARDIAC FAILURE2
Blood creatinine increased2
BLOOD CREATINE PHOSPHOKINASE INCREASED2
Balance disorder2
ARTHRALGIA2
ADVERSE DRUG REACTION2
Accidental exposure to product2
ACCIDENT2
Abnormal dreams2
Abdominal pain upper2
Wrong technique in product usage process1
Wrong product administered1
WRONG DRUG ADMINISTERED1
WEIGHT DECREASED1
VISUAL IMPAIRMENT1
Urticaria1
UPPER LIMB FRACTURE1
Unevaluable event1
ULNA FRACTURE1
TYPE 1 DIABETES MELLITUS1
TREATMENT NONCOMPLIANCE1
TRANSIENT PSYCHOSIS1
Toxicologic test abnormal1
Toxic epidermal necrolysis1
Tooth hypoplasia1
THYROID DISORDER1
THERAPEUTIC RESPONSE UNEXPECTED WITH DRUG SUBSTITUTION1
Therapeutic response unexpected1
THERAPEUTIC PRODUCT INEFFECTIVE1
TERMINAL INSOMNIA1
TENDON RUPTURE1
Tenderness1
Temperature regulation disorder1
TARDIVE DYSKINESIA1
Tachyphrenia1
Systemic lupus erythematosus1
SWOLLEN TONGUE1
SWELLING FACE1
SWELLING1
Surgery1
Subdural haemorrhage1
Stupor1
STOMACH DISCOMFORT1
Stevens-Johnson syndrome1
STATUS EPILEPTICUS1
STAPHYLOCOCCAL INFECTION1
Spinal artery thrombosis1
SPEECH DISORDER1
Somatic delusion1
Solar lentigo1
SNORING1
SLEEP DISORDER DUE TO A GENERAL MEDICAL CONDITION1
SKIN ULCER1
SEXUAL ABUSE1
SENSORY LOSS1
Sensorimotor disorder1
SELF-MEDICATION1
SELF INJURIOUS BEHAVIOUR1
Sedation complication1
SCREAMING1
SCIATICA1
Schizophrenia1
Scar1
Salivary hypersecretion1
Rheumatoid arthritis1
RESTLESS LEGS SYNDROME1
RESPIRATORY ACIDOSIS1
REFUSAL OF TREATMENT BY PATIENT1
Rectal haemorrhage1
Rebound effect1
RASH PAPULAR1
Quadriplegia1
Pupil fixed1
Psoriasis1
Pseudomembranous colitis1
Prostatic disorder1
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY1
Product use issue1
Product use in unapproved indication1
PRODUCT MEASURED POTENCY ISSUE1
Product expiration date issue1
Product communication issue1
Product administration error1
PRIAPISM1
Premature baby1
POSTURE ABNORMAL1
Poor quality product administered1
PHARYNGOLARYNGEAL PAIN1
PHARYNGEAL DISORDER1
PERSECUTORY DELUSION1
PERIPHERAL ISCHAEMIA1
PERIPHERAL ARTERIAL OCCLUSIVE DISEASE1
PCO2 DECREASED1
PARAESTHESIA ORAL1
Paraesthesia1
Pancreatitis chronic1
PANCREATITIS1
PALLOR1
PAINFUL ERECTION1
PAIN IN JAW1
PAIN1
Osteoarthritis1
Osmolar gap abnormal1
Organic brain syndrome1
OESOPHAGITIS1
OESOPHAGEAL DISCOMFORT1
Oedema1
OBSTRUCTIVE AIRWAYS DISORDER1
Normal newborn1
Non-alcoholic fatty liver1
Nocturia1
NIGHT SWEATS1
Neutropenia1
NEUROPATHY PERIPHERAL1
Nervous system disorder1
NERVE COMPRESSION1
Nephrosclerosis1
Neck pain1
NARCOTIC INTOXICATION1
MYOGLOBIN URINE PRESENT1
Myocarditis1
Myasthenia gravis1
MUTISM1
MUSCLE TWITCHING1
Muscle tightness1
MUSCLE SPASTICITY1
MUSCLE NECROSIS1
Multiple drug therapy1
MULTIPLE DRUG OVERDOSE ACCIDENTAL1
Movement disorder1
Mouth ulceration1
MOOD ALTERED1
Micturition disorder1
Metastases to prostate1
Metastases to liver1
Metastases to bone1
MENINGITIS TUBERCULOUS1
MACROCYTOSIS1
Lung disorder1
Loss of personal independence in daily activities1
LOSS OF EMPLOYMENT1
LIVER FUNCTION TEST ABNORMAL1
LIGAMENT RUPTURE1
Leukopenia1
LEG AMPUTATION1
Left ventricular hypertrophy1
Lactic acidosis1
Laceration1
Investigation1
Intestinal perforation1
Intestinal obstruction1
INTERCEPTED DRUG DISPENSING ERROR1
Intentional self-injury1
Intentional product use issue1
INJURY1
Injection site erythema1
INFLAMMATION1
INFECTIVE EXACERBATION OF CHRONIC OBSTRUCTIVE AIRWAYS DISEASE1
INCREASED APPETITE1
INADEQUATE ANALGESIA1
IMPRISONMENT1
IMPAIRED WORK ABILITY1
IMMOBILE1
Illness1
Hypoxic-ischaemic encephalopathy1
HYPOTHYROIDISM1
Hyporeflexia1
Hypopnoea1
Hypoglycaemia1
Hypoaesthesia1
Hyperthermia1
Hypertensive heart disease1
Hypertensive crisis1
Hypersomnia1
HYPERREFLEXIA1
Hyperosmolar hyperglycaemic state1
HYPERGLYCAEMIA1
HYPERAESTHESIA1
HOSTILITY1
Hospitalisation1
Homicidal ideation1
HEPATOMEGALY1
HEPATIC STEATOSIS1
HEPATIC FAILURE1
Hepatic enzyme increased1
HALLUCINATION, AUDITORY1
Haemorrhoidal haemorrhage1
HAEMOGLOBIN DECREASED1
HAEMATOCRIT DECREASED1
Gun shot wound1
Generalised tonic-clonic seizure1
Gastrointestinal necrosis1
Gastrointestinal motility disorder1
GANGRENE1
GAMMA-GLUTAMYLTRANSFERASE INCREASED1
Foetal exposure during pregnancy1
FLUID RETENTION1
FINGER AMPUTATION1
Femoral neck fracture1
FEELING OF DESPAIR1
FEELING COLD1
FAECAL INCONTINENCE1
Eye swelling1
Exposure during pregnancy1
Expired product administered1
EXCORIATION1
ERYTHEMA1
ERECTILE DYSFUNCTION1
Epistaxis1
Encephalopathy1
Emphysema1
ELECTROCARDIOGRAM T WAVE INVERSION1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
Echopraxia1
Eating disorder1
DYSKINESIA1
Dry skin1
Dry eye1
DRUG WITHDRAWAL HEADACHE1
Drug prescribing error1
DRUG LEVEL ABOVE THERAPEUTIC1
Drug ineffective for unapproved indication1
DISINHIBITION1
DIPLOPIA1
DILATATION VENTRICULAR1
Diabetic ketoacidosis1
DIABETIC COMA1
Depersonalisation/derealisation disorder1
DELUSION1
DEHYDRATION1
Decubitus ulcer1
Decreased appetite1
DEAFNESS NEUROSENSORY1
Cyanosis1
Crystalluria1
CROHN'S DISEASE1
Contusion1
Contraindicated product administered1
CONTINUOUS POSITIVE AIRWAY PRESSURE1
CONSCIOUSNESS FLUCTUATING1
Conjunctivitis1
Conduction disorder1
COMPARTMENT SYNDROME1
Coma scale abnormal1
Coma scale1
Coagulopathy1
CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR1
CIRCULATORY COLLAPSE1
Chest discomfort1
Cerebrovascular accident1
Cerebral atrophy1
Cardiac murmur1
CARDIAC FAILURE CONGESTIVE1
Calciphylaxis1
Caesarean section1
Bundle branch block left1
Bundle branch block1
BRUXISM1
Breast abscess1
Brain oedema1
Brain injury1
Brain herniation1
Brain death1
Bradyphrenia1
Bradykinesia1
BONE PAIN1
Bone marrow failure1
BODY TEMPERATURE DECREASED1
Body dysmorphic disorder1
BLOODY DISCHARGE1
Blood urea increased1
BLOOD TRIGLYCERIDES ABNORMAL1
BLOOD PRESSURE SYSTOLIC DECREASED1
BLOOD PRESSURE INCREASED1
BLOOD PRESSURE DIASTOLIC DECREASED1
Blood pressure decreased1
BLOOD PRESSURE ABNORMAL1
BLOOD OSMOLARITY INCREASED1
Blood lactic acid increased1
Blood glucose increased1
Blood disorder1
BLOOD CHOLESTEROL ABNORMAL1
Benzodiazepine drug level increased1
BEDRIDDEN1
BACTERIAL INFECTION1
BACK PAIN1
ATTENTION DEFICIT/HYPERACTIVITY DISORDER1
ASTHMA1
ASTHENIA1
ASPIRATION1
ASCITES1
ASBESTOSIS1
Arteriosclerosis1
ARRHYTHMIA1
APHASIA1
Aortic arteriosclerosis1
Anion gap increased1
Angioedema1
Anal haemorrhage1
ALCOHOL USE1
ALCOHOL POISONING1
ALANINE AMINOTRANSFERASE INCREASED1
Akathisia1
Affective disorder1
AFFECT LABILITY1
Adjustment disorder1
ACUTE PSYCHOSIS1
Acute kidney injury1
ACTIVITIES OF DAILY LIVING IMPAIRED1
Acquired immunodeficiency syndrome1
ACCIDENTAL DEATH1
Abdominal pain1
ABDOMINAL DISCOMFORT1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02545 281.8 Prelamin-A/C LMNA_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: respiratory
LD50: 1148 mg/kg



External links:

ChEBML: CHEMBL967
DrugBank: DB00231